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KMID : 0603519990040020068
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Journal of Korean Association of Cancer Prevention
1999 Volume.4 No. 2 p.68 ~ p.78
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Cancer Preventive Effects of Doenjang in vitro and in vivo - 1. Antimutagenic and in vivo Antitumor Effects of Doenjang -
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Park Kun-Young
Son Mi-Hyun
Moon Suk-Hee
Kim Kwang-Hyuk
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Abstract
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Antimutagenic and in vivo antitumor effects of doenjang (hexane, methanol and boiling extracts) were studied by using Ames test, SOS chromotest and Sarcoma-180 tumor cell-transplanted mice. The hexane, methanol and boiling extracts from doenjang showed strong antimutagenic activities (90∼91% inhibition) toward aflatoxin Bl (AFBl) in Salmonella typhimurium TA98 and TA100. In SOS chromotest using Escherichia coli PQ37, the extracts also exhibited strong antimutagenicity toward N-methyl-N’-nitro-N-nitrosoguanidine (MNNG). The solid tumor growth was inhibited when 5 ㎎/㎏ of the hexane, methanol and boiling extracts were administrated to the Balb/c mice by 64.0, 79.3 and 49.7%, respectively and the life span (prolongation effects) of the mice increased by 58.2%, 66.3% and 38.9%, respectively, showing the methanol extract was the highest effect. Spleen index, a marker for immunological activity, increased in the mice administrated the doenjang extracts compared to the control group. The phagocytic activity of the mice increased about twice by the treatment of the hexane extract. The nitroblue tetrazolium (NBT) reduction rate in the peritoneal phagocytic cells of the mice also increased about 3 times when the hexane extract was treated.
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KEYWORD
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Doenjang, Antimutagenicity, Sarcoma-180 cells, Antitumor, Phagocytic activity
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